High fat diet worsens Alzheimer's disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow.

doi:10.1038/s41598-020-65908-y

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Article

High fat diet worsens Alzheimer's disease-related behavioral abnormalities and neuropathology in APP/PS1 mice, but not by synergistically decreasing cerebral blood flow.

Scientific reports - 18 Jun 2020

Bracko Oliver, Vinarcsik Lindsay K, Cruz Hernández Jean C, Ruiz-Uribe Nancy E, Haft-Javaherian Mohammad, Falkenhain Kaja, Ramanauskaite Egle M, Ali Muhammad, Mohapatra Aditi, Swallow Madisen A, Njiru Brendah N, Muse Victorine, Michelucci Pietro E, Nishimura Nozomi, Schaffer Chris B

Abstract excerpt

Obesity is linked to increased risk for and severity of Alzheimer's disease (AD). Cerebral blood flow (CBF) reductions are an early feature of AD and are also linked to obesity. We recently showed that non-flowing capillaries, caused by adhered neutrophils, contribute to CBF reduction in mouse models of AD. Because obesity could exacerbate the vascular inflammation likely underlying this neutrophil adhesion, we...

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PMID: 32555372
DOI: 10.1038/s41598-020-65908-y
PMCID: PMC7303150

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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