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Article

A pilot study investigating the effects of voluntary exercise on capillary stalling and cerebral blood flow in the APP/PS1 mouse model of Alzheimer's disease.

PloS one - 1 Jan 2020

Falkenhain Kaja, Ruiz-Uribe Nancy E, Haft-Javaherian Mohammad, Ali Muhammad, Michelucci Pietro E, Schaffer Chris B, Bracko Oliver

Abstract excerpt

Exercise exerts a beneficial effect on the major pathological and clinical symptoms associated with Alzheimer's disease in humans and mouse models of the disease. While numerous mechanisms for such benefits from exercise have been proposed, a clear understanding of the causal links remains elusive. Recent studies also suggest that cerebral blood flow in the brain of both Alzheimer's patients and mouse models of...

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PMID: 32857763
DOI: 10.1371/journal.pone.0235691
PMCID: PMC7455035

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