Article

A complete collagen IV fluorophore knock-in toolkit reveals α-chain diversity in basement membrane

2024-12-17

Abstract excerpt

The type IV collagen triple helix, composed of three ⍺-chains, is a core basement membrane (BM) component that assembles into a network within BMs. Endogenous tagging of all ⍺-chains with genetically encoded fluorophores has remained elusive, limiting our understanding of this crucial BM component. Through genome editing, we show that the C-termini of the C. elegans type IV collagen ⍺-chains EMB-9 and LET-2...

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Literature Corpus work: 267816e4-fec7-51c4-a716-c66171b0fd8a
DOI: 10.1101/2024.12.14.628508

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