Article

Intermediate filament network perturbation in the <i>C. elegans</i> intestine causes systemic toxicity

2022-08-07

Abstract excerpt

Intermediate filaments (IFs) are major components of the metazoan cytoskeleton. A long-standing debate concerns the question whether IF network organization only reflects or also determines cell and tissue function. Using C. elegans , we have recently described mutants of the MAPK SMA-5, which perturb the organization of the intestinal IF cytoskeleton resulting in luminal widening and cytoplasmic invaginations. B...

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Literature Corpus work: 5fc4d1f4-bd12-5eeb-b2ed-f5564aad5ed4
DOI: 10.1101/2022.08.07.503108

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