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Article

Actin activates Pseudomonas aeruginosa ExoY nucleotidyl cyclase toxin and ExoY-like effector domains from MARTX toxins.

Nature communications - 5 Dec 2016

Belyy Alexander, Raoux-Barbot Dorothée, Saveanu Cosmin, Namane Abdelkader, Ogryzko Vasily, Worpenberg Lina, David Violaine, Henriot Veronique, Fellous Souad, Merrifield Christien, Assayag Elodie, Ladant Daniel, Renault Louis, Mechold Undine

Abstract excerpt

The nucleotidyl cyclase toxin ExoY is one of the virulence factors injected by the Pseudomonas aeruginosa type III secretion system into host cells. Inside cells, it is activated by an unknown eukaryotic cofactor to synthesize various cyclic nucleotide monophosphates. ExoY-like adenylate cyclases are also found in Multifunctional-Autoprocessing Repeats-in-ToXin (MARTX) toxins produced by various Gram-negative...

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PMID: 27917880
DOI: 10.1038/ncomms13582
PMCID: PMC5150216

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