Article
Identification and characterization of SpcU, a chaperone required for efficient secretion of the ExoU cytotoxin.
Journal of bacteriology - 1 Dec 1998
Finck-Barbançon V, Yahr T L, Frank D W
Abstract excerpt
In recent studies, we have shown that Pseudomonas aeruginosa strains that are acutely cytotoxic in vitro damage the lung epithelium in vivo. Genetic analysis indicated that the factor responsible for acute cytotoxicity was controlled by ExsA and therefore was part of the exoenzyme S regulon. The...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Bacterial Toxins
- Binding Sites
- Cytotoxins
- Escherichia coli
- Genes, Bacterial
- Genetic Complementation Test
- Humans
- Molecular Chaperones
- Molecular Sequence Data
- Mutation
- Open Reading Frames
- Operon
- Pseudomonas aeruginosa
- Recombinant Proteins
- Virulence