Article
ExoU Induces Lung Endothelial Cell Damage and Activates Pro-Inflammatory Caspase-1 during Pseudomonas aeruginosa Infection.
Toxins - 18 Feb 2022
Hardy Kierra S, Tuckey Amanda N, Renema Phoibe, Patel Mita, Al-Mehdi Abu-Bakr, Spadafora Domenico, Schlumpf Cody A, Barrington Robert A, Alexeyev Mikhail F, Stevens Troy, Pittet Jean-Francois, Wagener Brant M, Simmons Jon D, Alvarez Diego F, Audia Jonathon P
Abstract excerpt
The Gram-negative, opportunistic pathogen Pseudomonas aeruginosa utilizes a type III secretion system to inject exoenzyme effectors into a target host cell. Of the four best-studied exoenzymes, ExoU causes rapid cell damage and death. ExoU is a phospholipase A2 (PLA2) that hydrolyses host cell membranes, and P. aeruginosa strains expressing ExoU are associated with poor outcomes in critically ill patients with...
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