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Article

The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU.

The EMBO journal - 16 Jun 2003

Sato Hiromi, Frank Dara W, Hillard Cecilia J, Feix Jimmy B, Pankhaniya Ravi R, Moriyama Kiyoshi, Finck-Barbançon Viviane, Buchaklian Adam, Lei Ming, Long Roy M, Wiener-Kronish Jeanine, Sawa Teiji

Abstract excerpt

Pseudomonas aeruginosa delivers the toxin ExoU to eukaryotic cells via a type III secretion system. Intoxication with ExoU is associated with lung injury, bacterial dissemination and sepsis in animal model and human infections. To search for ExoU targets in a genetically tractable system, we used controlled expression of the toxin in Saccharomyces cerevisiae. ExoU was cytotoxic for yeast and caused a vacuolar...

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Identifiers

PMID: 12805211
DOI: 10.1093/emboj/cdg290
PMCID: PMC162142

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The mechanism of action of the Pseudomonas aeruginosa-encoded type III cytotoxin, ExoU.PMID 12805211Read ↗

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