Mutation of the phospholipase catalytic domain of the Pseudomonas aeruginosa cytotoxin ExoU abolishes colonization promoting activity and reduces corneal disease severity.

doi:10.1016/j.exer.2007.08.015

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Article

Mutation of the phospholipase catalytic domain of the Pseudomonas aeruginosa cytotoxin ExoU abolishes colonization promoting activity and reduces corneal disease severity.

Experimental eye research - 1 Dec 2007

Tam C, Lewis S E, Li W Y, Lee E, Evans D J, Fleiszig S M J

Abstract excerpt

We have previously shown that ExoU, a type III secreted cytotoxin of Pseudomonas aeruginosa, causes acute cytotoxicity towards corneal epithelial cells in vitro, and contributes to corneal disease pathology and ocular colonization in vivo. Subsequently, we reported that ExoU represses phagocyte infiltration of infected corneas in vivo. ExoU has patatin-like phospholipase activity that is required for cytotoxic...

Topics

Animals
Bacterial Proteins
Catalytic Domain
Cells, Cultured
Eye Infections, Bacterial
Humans
Keratitis
Leukocidins
Mice
Mice, Inbred C57BL
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phospholipases

Pseudomonas Infections

Pseudomonas aeruginosa

Severity of Illness Index

Time Factors

Virulence

Source

Open in PubMed Open full text

Identifiers

PMID: 17905228
DOI: 10.1016/j.exer.2007.08.015
PMCID: PMC3213055

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