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Engineering human pluripotent stem cells into a functional skeletal muscle tissue

3 Jan 2018

Abstract excerpt

The generation of functional skeletal muscle tissues from human pluripotent stem cells (hPSCs) has not been reported. Here, we derive induced myogenic progenitor cells (iMPCs) via transient overexpression of Pax7 in paraxial mesoderm cells differentiated from hPSCs. In 2D culture, iMPCs readily differentiate into spontaneously contracting multinucleated myotubes and a pool of satellite-like cells endogenously...

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3D Printing in Biomedical Research
Pluripotent Stem Cells Research
Tissue Engineering and Regenerative Medicine

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29317646
DOI: 10.1038/s41467-017-02636-4

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