Article

Native extracellular matrix promotes human neuromuscular organoid morphogenesis and function

2023-05-19

Abstract excerpt

Human neuromuscular organoids (NMOs) derived from induced pluripotent stem cells (hiPSCs) hold a great potential to study (dys)functional human skeletal muscle (SkM) in vitro. The three-dimensional (3D) self-assembly of NMOs leads to the generation of spheroids, whose 3D organization cannot be controlled. Indeed, proper development, maturation and function of the innervated SkM require a well-defined multiscale 3D...

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Literature Corpus work: a9b52eee-1d7a-59cf-a373-78a4585e0dd7
DOI: 10.1101/2023.05.19.541464

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