Engineering a 3D in vitro model of human skeletal muscle at the single fiber scale

Abstract excerpt

The reproduction of reliable in vitro models of human skeletal muscle is made harder by the intrinsic 3D structural complexity of this tissue. Here we coupled engineered hydrogel with 3D structural cues and specific mechanical properties to derive human 3D muscle constructs ("myobundles") at the scale of single fibers, by using primary myoblasts or myoblasts derived from embryonic stem cells. To this aim, cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 3D Printing in Biomedical Research
• Share to Muscle Physiology and Disorders
• Share to Tissue Engineering and Regenerative Medicine