Article

Long-Term Functional 3D Human Skeletal Muscle Constructs from Human Induced Pluripotent Stem Cells Enable Electrically Controlled Remodelling Studies

2025-09-03

Abstract excerpt

Studying skeletal muscle remodelling across large temporal scales is difficult because most 3D tissue-engineered skeletal muscle (3D-TESM) models cannot sustain stable development over prolonged culture. Skeletal muscle adaptations in vivo are strongly influenced by changes in tissue length, but most TESM models are mechanically restrictive, limiting elongation and thereby constraining structural remodelling. The...

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Literature Corpus work: ebfc1582-1e93-5094-9d6f-2a10a98d3b7a
DOI: 10.1101/2025.08.28.672872

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