Article

Epigenetic regulator UHRF1 suppressively orchestrates multiple pathogenesis in rheumatoid arthritis.

2021-03-03

Abstract excerpt

<title>Abstract</title> <p>Rheumatoid arthritis (RA) is characterized by chronic synovial inflammation with aberrant epigenetic alterations, eventually leading to joint destruction. However, epigenetic regulatory mechanisms underlying RA pathogenesis remain largely unknown. Here, we showed that Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) , a key molecule involved in maintenance of DNA methylat...

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Literature Corpus work: bb7840b8-6b31-5a04-85c2-15f40522627a
DOI: 10.21203/rs.3.rs-293501/v1

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