Article

Bridging the gap between <i>in silico</i> and <i>in vivo:</i> modeling opioid disposition in a kidney proximal tubule microphysiological system

2020-12-06

Abstract excerpt

<h4>Background</h4> Opioid overdose, dependence, and addiction are a major public health crisis. Patients with chronic kidney disease (CKD) are at high risk of opioid overdose, therefore novel methods that provide accurate prediction of kidney clearance (CL r ) and systemic disposition of opioids in CKD patients can facilitate the optimization of therapeutic regimens. <h4>Methods</h4> We conducted prediction o...

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Literature Corpus work: 26149b7a-2027-50a4-bc03-99d68ee9e3c3
DOI: 10.1101/2020.12.04.412239

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