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Article

Drugdrug interactions involving membrane transporters in the human kidney

21 Jul 2006

Abstract excerpt

The kidneys play a critical role in the elimination of xenobiotics. Factors affecting the ability of the kidney to eliminate drugs may result in marked changes in the pharmacokinetics of a given compound. Drug-drug interactions due to competitive inhibition of renal organic anion or cation secretion systems have been noticed clinically for a long time. However, our understanding of the physical sites of...

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PMID: 16859401
DOI: 10.1517/17425255.2.4.505

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