Article

Lineage-Specific Differences and Regulatory Networks Governing Human Chondrocyte Development

2022-05-25

Abstract excerpt

To address large gaps in our understanding of the molecular regulation of articular and growth plate cartilage development in humans, we used our directed differentiation approach to generate these distinct cartilage tissues from human embryonic stem cells. The resulting transcriptomic profiles of hESC-derived articular and growth plate chondrocytes were similar to fetal epiphyseal and growth plate chondrocytes, w...

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Literature Corpus work: a5758eac-d475-562c-a3f8-ca719a4af9ec
DOI: 10.1101/2022.05.25.493388

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