Article
Lamina-associated polypeptide 1: protein interactions and tissue-selective functions.
Seminars in cell & developmental biology - 1 May 2014
Shin Ji-Yeon, Dauer William T, Worman Howard J
Abstract excerpt
Mutations in genes encoding widely expressed nuclear envelope proteins often lead to diseases that manifest in specific tissues. Lamina-associated polypeptide 1 (LAP1) is an integral protein of the inner nuclear membrane that is expressed in most cells and tissues. Within the nuclear envelope, LAP1 interacts physically with lamins, torsinA and emerin, suggesting it may serve as a key node for transducing signals...
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