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<i>The human GRK4γ 65L variant</i> causes salt-sensitive hypertension by increasing renal SLC4A5 expression through the HDAC1 pathway

2026-03-11

Abstract excerpt

Salt-sensitive hypertension, a condition in which the blood pressure (BP) increases with an increase in salt intake, is influenced by behavioral, genetic, and environmental factors. Salt sensitivity is associated with variants of the G protein-coupled receptor kinase 4γ (GRK4γ) and the renal sodium bicarbonate cotransporter 2 (NBCe2), encoded by the solute carrier family 4 member 5 ( SLC4A5 ). The R>65L variant...

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Literature Corpus work
260e9513-16c2-5f7a-858c-6cf670ad44ad
DOI
10.64898/2026.03.09.710443
Open publication

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<i>The human GRK4γ 65L variant</i> causes salt-sensitive hypertension by increasing renal SLC4A5 expression through the HDAC1 pathwayDOI 10.64898/2026.03.09.710443
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