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Article

G protein-coupled receptor kinase 4 gene variants in human essential hypertension.

Proceedings of the National Academy of Sciences of the United States of America - 19 Mar 2002

Felder Robin A, Sanada Hironobu, Xu Jing, Yu Pei-Ying, Wang Zheng, Watanabe Hidetsuna, Asico Laureano D, Wang Wei, Zheng Shaopeng, Yamaguchi Ikuyo, Williams Scott M, Gainer James, Brown Nancy J, Hazen-Martin Debra, Wong Lee-Jun C, Robillard Jean E, Carey Robert M, Eisner Gilbert M, Jose Pedro A

Abstract excerpt

Essential hypertension has a heritability as high as 30-50%, but its genetic cause(s) has not been determined despite intensive investigation. The renal dopaminergic system exerts a pivotal role in maintaining fluid and electrolyte balance and participates in the pathogenesis of genetic hypertens...

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Identifiers

PMID: 11904438
DOI: 10.1073/pnas.062694599
PMCID: PMC122616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-11904438-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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