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Article

The epithelial sodium channel γ-subunit gene and blood pressure: family based association, renal gene expression, and physiological analyses.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2011

Büsst Cara J, Bloomer Lisa D S, Scurrah Katrina J, Ellis Justine A, Barnes Timothy A, Charchar Fadi J, Braund Peter, Hopkins Paul N, Samani Nilesh J, Hunt Steven C, Tomaszewski Maciej, Harrap Stephen B

Abstract excerpt

Variants in the gene encoding the γ-subunit of the epithelial sodium channel (SCNN1G) are associated with both Mendelian and quantitative effects on blood pressure. Here, in 4 cohorts of 1611 white European families composed of a total of 8199 individuals, we undertook staged testing of candidate single-nucleotide polymorphisms for SCNN1G (supplemented with imputation based on data from the 1000 Genomes Project)...

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Identifiers

PMID: 22006290
DOI: 10.1161/HYPERTENSIONAHA.111.176370
PMCID: PMC3220739

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