Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis.

Human molecular genetics - 1 Mar 2012

Gröger Nicole, Vitzthum Helga, Fröhlich Henning, Krüger Marcus, Ehmke Heimo, Braun Thomas, Boettger Thomas

Abstract excerpt

The human SLC4A5 gene has been identified as a hypertension susceptibility gene based on the association of single nucleotide polymorphisms with blood pressure (BP) levels and hypertension status. The biochemical basis of this association is unknown particularly since no single gene variant was linked to hypertension in humans. SLC4A5 (NBCe2, NBC4) is expressed in the collecting duct of the kidney and acts as an...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acidosis, Renal Tubular
Share to Aldosterone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Atrial Natriuretic Factor

Share to Blood Chemical Analysis

Share to Kidney Tubules

Share to Sodium-Bicarbonate Symporters

Source

Identifiers

PMID: 22082831
DOI: 10.1093/hmg/ddr533

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted mutation of SLC4A5 induces arterial hypertension and renal metabolic acidosis.PMID 22082831Read ↗

Sodium bicarbonate cotransporter NBCe2 gene variants increase sodium and bicarbonate transport in human renal proximal tubule cells.Semantic proximity Read ↗

Salt sensitivity of blood pressure is associated with polymorphisms in the sodium-bicarbonate cotransporter.Semantic proximity Read ↗

[Physiology and pathophysiology of Na⁺/HCO₃⁻ cotransporter NBCe1].Semantic proximity Read ↗

From protein uptake to Dent disease: An overview of the CLCN5 gene.Semantic proximity Read ↗

Unravelling the Genetic Basis of Primary Aldosteronism.Semantic proximity Read ↗

New insights into aldosterone-producing adenomas and hereditary aldosteronism: mutations in the K+ channel KCNJ5.Semantic proximity Read ↗

Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.Semantic proximity Read ↗

Rare mutations in renal sodium and potassium transporter genes exhibit impaired transport function.Semantic proximity Read ↗

K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension.Semantic proximity Read ↗

Renal phenotype in mice lacking the Kir5.1 (Kcnj16) K+ channel subunit contrasts with that observed in SeSAME/EAST syndrome.Semantic proximity Read ↗

Familial renal tubular acidosis.Semantic proximity Read ↗

Resequencing Epithelial Sodium Channel Genes Identifies Rare Variants Associated With Blood Pressure Salt-Sensitivity: The GenSalt Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.