Article

HTLV-1-infected cells drive the differentiation of monocytes into macrophages in vitro

2024-05-15

Abstract excerpt

<title>Abstract</title> <p><bold>Background.</bold> The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that causes HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HAM/TSP is a chronic inflammatory neurodegenerative disease characterized by leukocyte infiltration in the spinal cord. T-lymphocytes are the most important targets of HTLV-1 infection, but monocytes are also infect...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 26023c99-bcc4-571b-9615-8902172f774c
DOI: 10.21203/rs.3.rs-4359860/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HTLV-1-infected cells drive the differentiation of monocytes into macrophages in vitroDOI 10.21203/rs.3.rs-4359860/v1Read

Deciphering HTLV-1-associated Lung Pathology through Integrated in vitro and Multi-cohort Multi-omics Analysis: Inflammation, Monocyte Recruitment and Differentiation Triggered by HTLV-1-exposed Alveolar Epithelial CellsSemantic proximity Read

HTLV-1-Derived Exosomes Drive Transcriptional Reprogramming of Monocytes Toward a Mixed M1/M2 Phenotype in HAM/TSP.Semantic proximity Read

Transcriptional reprogramming in immune cells of HTLV-1 asymptomatic carriers and HAM/TSP patients following antiretroviral therapySemantic proximity Read

Single-cell transcriptomic landscape identifies the expansion of peripheral blood monocytes as an indicator of HIV-1-TB co-infectionSemantic proximity Read

Co-Infection and Cancer: Host–Pathogen Interaction between Dendritic Cells and HIV-1, HTLV-1, and Other Oncogenic VirusesSemantic proximity Read

Peculiar transcriptional reprogramming with functional impairment of dendritic cells upon exposure to transformed HTLV-1-infected cellsSemantic proximity Read

Decades Long Involvement of THP-1 Cells as a Model for Macrophage Research: A Comprehensive ReviewSemantic proximity Read

HIV-1 promotes cell-to-cell interactions enabling spread from CD4+ T cells to microgliaSemantic proximity Read

HIV-1 infection of human microglia activates inflammatory pathways associated with HIV-associated neurocognitive disorders (HAND)Semantic proximity Read

Single-cell analysis of CD14+CD16+ monocytes identifies a subpopulation with an enhanced migratory and inflammatory phenotype.Semantic proximity Read

Comparative transcriptomics of THP-1 monocytes in response to different pathogensSemantic proximity Read

Myeloid Cell Interaction with HIV: A Complex RelationshipSemantic proximity Read