Article

Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast Cancer

2025-08-22

Abstract excerpt

<h4>ABSTRACT</h4> Despite the success of endocrine therapy (ET) in treating hormone receptor-positive breast cancer, a significant proportion of patients relapse during or after treatment, making ET resistance a major clinical challenge. Previously we have shown that ET-resistant breast cancer cells exhibit reduced ceramide levels and an increased sensitivity to ceramide-induced cell death. Here, we demonstrate t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 25f0fa87-cccd-546b-95b9-31e9e0365782
DOI: 10.1101/2025.08.18.670862

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ceramide-induced Endoplasmic Reticulum Stress as a Targetable Vulnerability in Endocrine Therapy-Resistant Breast CancerDOI 10.1101/2025.08.18.670862Read

Association of tamoxifen resistance and lipid reprogramming in breast cancerSemantic proximity Read

Endoplasmic Reticulum Stress, the Unfolded Protein Response, Autophagy, and the Integrated Regulation of Breast Cancer Cell FateSemantic proximity Read

Lipid Metabolism Reprogramming and Trastuzumab Resistance in Breast Cancer Cell Lines Overexpressing the ERBB2 Membrane ReceptorSemantic proximity Read

Endocrine resistance in hormone-responsive breast cancer: mechanisms and therapeutic strategies.Semantic proximity Read

Endocrine resistance in breast cancer--An overview and update.Semantic proximity Read

Epigenetic Regulation of Autophagy in Breast Cancer: Implications for Biomarker Discovery and Personalized Therapy.Semantic proximity Read

Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells.Semantic proximity Read

ESR1-Activating Mutations Confer Metabolic Vulnerabilities in ER+ Breast Cancer.Semantic proximity Read

Emerging Roles of Ceramides in Breast Cancer Biology and TherapySemantic proximity Read

PML1-Mediated Feedforward Loop Through PI3K and MAPK Axes Drives Endocrine ResistanceSemantic proximity Read

Lipid metabolic reprogramming drives triglyceride storage and variable sensitivity to FASN inhibition in endocrine-resistant breast cancer cellsSemantic proximity Read

Lipid Metabolism Reprogramming Is Associated with Trastuzumab Resistance in ERBB2+ Breast Cancer Cell LinesSemantic proximity Read