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Article

Gene network signaling in hormone responsiveness modifies apoptosis and autophagy in breast cancer cells.

The Journal of steroid biochemistry and molecular biology - 1 Mar 2009

Clarke Robert, Shajahan Ayesha N, Riggins Rebecca B, Cho Younsook, Crawford Anatasha, Xuan Jianhua, Wang Yue, Zwart Alan, Nehra Ruchi, Liu Minetta C

Abstract excerpt

Resistance to endocrine therapies, whether de novo or acquired, remains a major limitation in the ability to cure many tumors that express detectable levels of the estrogen receptor alpha protein (ER). While several resistance phenotypes have been described, endocrine unresponsiveness in the context of therapy-induced tumor growth appears to be the most prevalent. The signaling that regulates endocrine resistant...

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Source

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Identifiers

PMID: 19444933
DOI: 10.1016/j.jsbmb.2008.12.023
PMCID: PMC2768542

Genes

BCL2
BECN1
SQSTM1
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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