Article

Lipid metabolic reprogramming drives triglyceride storage and variable sensitivity to FASN inhibition in endocrine-resistant breast cancer cells

2024-06-03

Abstract excerpt

<h4>Background</h4> Lipid metabolic reprogramming is increasingly recognized as a hallmark of endocrine resistance in estrogen receptor-positive (ER+) breast cancer. In this study, we investigated alterations in lipid metabolism in ER+ breast cancer cell lines with acquired resistance to common endocrine therapies and evaluated the efficacy of a clinically relevant fatty acid synthase (FASN) inhibitor. <h4>Method...

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Literature Corpus work: e942e255-18ff-512b-967b-dd016812fe01
DOI: 10.1101/2024.05.30.596684

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