Article

Single-cell analysis reveals shared and stage-specific features of the human skin response in primary and secondary syphilis lesions

2026-08-28

Abstract excerpt

<title>Abstract</title> Syphilis, caused by Treponema pallidum subspecies pallidum (TPA), is a resurging global health threat whose complex immunobiology is poorly recapitulated by animal models. We integrated single-cell transcriptomics with tissue and cellular analyses to define immune responses in freshly obtained skin and blood during primary and secondary syphilis. IL1B⁺ macrophages dominated the macropha...

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Literature Corpus work: b464b74d-4372-5cc9-b7b8-55d3f25defe5
DOI: 10.21203/rs.3.rs-10765906/v1

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