Article

Genetic Variation at 19q13.33 confers colorectal cancer risk through the interaction of mucosal expression of FUT2 and plasma vitamin B12 levels

2026-07-14

Abstract excerpt

<h4>Introduction</h4> Genome-wide association studies have identified a common variant at chr19q13.33 within the FUT2 locus as a determinant of colorectal cancer (CRC) susceptibility, with each risk allele conferring an approximately 7% increase in risk (OR 1.07, P = 6.11×10⁻¹⁰). This locus regulates expression of FUT2, a fucosyltransferase involved in α-1,2 glycosylation, and has also been associated with circu...

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Literature Corpus work: 25d885d3-2461-5d16-9bc5-33a62da5b441
DOI: 10.64898/2026.07.10.26357741

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