FUT2 promotes colorectal cancer metastasis by reprogramming fatty acid metabolism via YAP/TAZ signaling and SREBP-1

Abstract excerpt

<title>Abstract</title> <p>Colorectal cancer (CRC) ranks as the second most lethal cancer worldwide because of high rate of metastasis, approximately 20% of CRC patients have metastases at initial diagnosis. Metabolism reprogramming, as a universal feature for cancer cells, is considered to be associated with metastasis. We have previously demonstrated that fucosyltransferase 2 (FUT2) functions as a potent oncoge...

Topics

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• Autophagy in Disease and Therapy
• Cancer, Hypoxia, and Metabolism
• Cancer, Lipids, and Metabolism
• Colorectal Cancer Treatments and Studies
• Epigenetics and DNA Methylation
• Glycosylation and Glycoproteins Research
• Liver Disease Diagnosis and Treatment
• RNA modifications and cancer

Identifiers and source

Literature Corpus work

c35f2fe1-1ad0-574b-ac7f-47354d7b2af4

DOI

10.21203/rs.3.rs-4316893/v1