Article
Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease.
Human molecular genetics - 1 Sept 2010
McGovern Dermot P B, Jones Michelle R, Taylor Kent D, Marciante Kristin, Yan Xiaofei, Dubinsky Marla, Ippoliti Andy, Vasiliauskas Eric, Berel Dror, Derkowski Carrie, Dutridge Deb, Fleshner Phil, Shih David Q, Melmed Gil, Mengesha Emebet, King Lily, Pressman Sheila, Haritunians Talin, Guo Xiuqing, Targan Stephan R, Rotter Jerome I
Abstract excerpt
Genetic variation in both innate and adaptive immune systems is associated with Crohn's disease (CD) susceptibility, but much of the heritability to CD remains unknown. We performed a genome-wide association study (GWAS) in 896 CD cases and 3204 healthy controls all of Caucasian origin as defined by multidimensional scaling. We found supportive evidence for 21 out of 40 CD loci identified in a recent CD GWAS...
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