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Article

FUT2-mediated α1,2-fucosylation in inflammatory bowel disease: mechanisms and translational potential.

Molecular biology reports - 22 Jul 2026

Chen Jin, Gan Li, Zhang Shuhong, Liao Shengtao, Lv Lin

Abstract excerpt

Inflammatory bowel disease (IBD) arises from complex interactions among genetic susceptibility, immune dysregulation, the intestinal microbiota and environmental factors. Fucosyltransferase 2 (FUT2) regulates mucosal α1,2-fucosylation and the expression of histo-blood group antigens (HBGAs), thereby shaping host-microbe interactions at the intestinal surface. Loss-of-function FUT2 variants define the non-secretor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42484923
DOI: 10.1007/s11033-026-12396-4

Genes

FUT2
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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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