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Article

Reprograming of gut microbiome energy metabolism by the <i>FUT2</i> Crohn’s disease risk polymorphism

29 Apr 2014

Abstract excerpt

Fucosyltransferase 2 (FUT2) is an enzyme that is responsible for the synthesis of the H antigen in body fluids and on the intestinal mucosa. The H antigen is an oligosaccharide moiety that acts as both an attachment site and carbon source for intestinal bacteria. Non-secretors, who are homozygous for the loss-of-function alleles of FUT2 gene (sese), have increased susceptibility to Crohn's disease (CD). To...

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PMID: 24781901
DOI: 10.1038/ismej.2014.64

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