Article
Association between antibiotic use during early life and early-onset colorectal cancer risk overall and according to polygenic risk and FUT2 genotypes.
International journal of cancer - 1 Nov 2023
Jiang Fangyuan, Boakye Daniel, Sun Jing, Wang Lijuan, Yu Lili, Zhou Xuan, Zhao Jianhui, Bian Zilong, Song Peige, He Yazhou, Zhu Yingshuang, Chen Jie, Yuan Shuai, Song Mingyang, Larsson Susanna C, Giovannucci Edward L, Theodoratou Evropi, Ding Kefeng, Li Xue
Abstract excerpt
Early-onset colorectal cancer (EOCRC) has been increasing worldwide. Potential risk factors may have occurred in childhood or adolescence. We investigated the associations between early-life factors and EOCRC risk, with a particular focus on long-term or recurrent antibiotic use (LRAU) and its interaction with genetic factors. Data on the UK Biobank participants recruited between 2006 and 2010 and followed up to...
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