Article
A genome-wide association meta-analysis of diarrhoeal disease in young children identifies FUT2 locus and provides plausible biological pathways.
Human molecular genetics - 15 Sept 2016
Bustamante Mariona, Standl Marie, Bassat Quique, Vilor-Tejedor Natalia, Medina-Gomez Carolina, Bonilla Carolina, Ahluwalia Tarunveer S, Bacelis Jonas, Bradfield Jonathan P, Tiesler Carla M T, Rivadeneira Fernando, Ring Susan, Vissing Nadja H, Fink Nadia R, Jugessur Astanand, Mentch Frank D, Ballester Ferran, Kriebel Jennifer, Kiefte-de Jong Jessica C, Wolsk Helene M, Llop Sabrina, Thiering Elisabeth, Beth Systke A, Timpson Nicholas J, Andersen Josefine, Schulz Holger, Jaddoe Vincent W V, Evans David M, Waage Johannes, Hakonarson Hakon, Grant Struan F A, Jacobsson Bo, Bønnelykke Klaus, Bisgaard Hans, Davey Smith George, Moll Henriette A, Heinrich Joachim, Estivill Xavier, Sunyer Jordi
Abstract excerpt
More than a million childhood diarrhoeal episodes occur worldwide each year, and in developed countries a considerable part of them are caused by viral infections. In this study, we aimed to search for genetic variants associated with diarrhoeal disease in young children by meta-analyzing genome-wide association studies, and to elucidate plausible biological mechanisms. The study was conducted in the context of...
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