Article
Systematic mining of fungal chimeric terpene synthases using an efficient precursor-providing yeast chassis.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2021
Chen Rong, Jia Qidong, Mu Xin, Hu Ben, Sun Xiang, Deng Zixin, Chen Feng, Bian Guangkai, Liu Tiangang
Abstract excerpt
Chimeric terpene synthases, which consist of C-terminal prenyltransferase (PT) and N-terminal class I terpene synthase (TS) domains (termed PTTSs here), is unique to fungi and produces structurally diverse di- and sesterterpenes. Prior to this study, 20 PTTSs had been functionally characterized. Our understanding of the origin and functional evolution of PTTS genes is limited. Our systematic search of sequenced...
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