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Article

Tuning aromatic cage occupancy in prenyltransferases enables selective and efficient production of rare c-prenylated flavonoids.

Nature communications - 19 Feb 2026

Qiu Ruiying, Huang Huisi, Chi Junxi, Gao Longwei, Gao Qilin, Li Min, Cai Menghao, Yu Haishuang, Wang Shijie, Qian Zhilan, Jiang Minchuan, Liu Yu, Chen Bo, Zhou Yang, Zhang Zhi-Min, Wang Jian-Bo

Abstract excerpt

C-prenylated flavonoids possess notable pharmaceutical potential, but their production is hindered by the challenging selective prenylation of their unstable polyphenolic cores. Natural prenyltransferases offer a direct route but suffer from low activity and incomplete mechanistic understanding. Here, we report a directed evolution strategy to reshape the active pocket of the prenyltransferase AtaPT, uncovering...

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PMID: 41714621
DOI: 10.1038/s41467-026-69706-4
PMCID: PMC13031432

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