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Article

1.55Å-resolution structure of ent-copalyl diphosphate synthase and exploration of general acid function by site-directed mutagenesis.

Biochimica et biophysica acta - 1 Jan 2014

Köksal Mustafa, Potter Kevin, Peters Reuben J, Christianson David W

Abstract excerpt

BACKGROUND: The diterpene cyclase ent-copalyl diphosphate synthase (CPS) catalyzes the first committed step in the biosynthesis of gibberellins. The previously reported 2.25Å resolution crystal structure of CPS complexed with (S)-15-aza-14,15-dihydrogeranylgeranyl thiolodiphosphate (1) established the αβγ domain architecture, but ambiguities regarding substrate analog binding remained. METHOD: Use of...

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Identifiers

PMID: 24036329
DOI: 10.1016/j.bbagen.2013.09.004
PMCID: PMC3859867

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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