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Article

Identification of key amino acid residues determining product specificity of 2,3-oxidosqualene cyclase in Oryza species.

The New phytologist - 1 May 2018

Xue Zheyong, Tan Zhengwei, Huang Ancheng, Zhou Yuan, Sun Juncong, Wang Xiaoning, Thimmappa Ramesha B, Stephenson Michael J, Osbourn Anne, Qi Xiaoquan

Abstract excerpt

Triterpene synthases, also known as 2,3-oxidosqualene cyclases (OSCs), synthesize diverse triterpene skeletons that form the basis of an array of functionally divergent steroids and triterpenoids. Tetracyclic and pentacyclic triterpene skeletons are synthesized via protosteryl and dammarenyl cations, respectively. The mechanism of conversion between two scaffolds is not well understood. Here, we report a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 29528490
DOI: 10.1111/nph.15080

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