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Article

Structural elucidation of cisoid and transoid cyclization pathways of a sesquiterpene synthase using 2-fluorofarnesyl diphosphates.

ACS chemical biology - 16 Apr 2010

Noel Joseph P, Dellas Nikki, Faraldos Juan A, Zhao Marylin, Hess B Andes, Smentek Lidia, Coates Robert M, O'Maille Paul E

Abstract excerpt

Sesquiterpene skeletal complexity in nature originates from the enzyme-catalyzed ionization of (trans,trans)-farnesyl diphosphate (FPP) (1a) and subsequent cyclization along either 2,3-transoid or 2,3-cisoid farnesyl cation pathways. Tobacco 5-epi-aristolochene synthase (TEAS), a transoid synthas...

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Identifiers

PMID: 20175559
DOI: 10.1021/cb900295g
PMCID: PMC2860371

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20175559-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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