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Article

Plasmid-mediated metronidazole resistance in Clostridioides difficile.

Nature communications - 30 Jan 2020

Boekhoud Ilse M, Hornung Bastian V H, Sevilla Eloisa, Harmanus Céline, Bos-Sanders Ingrid M J G, Terveer Elisabeth M, Bolea Rosa, Corver Jeroen, Kuijper Ed J, Smits Wiep Klaas

Abstract excerpt

Metronidazole was until recently used as a first-line treatment for potentially life-threatening Clostridioides difficile (CD) infection. Although cases of metronidazole resistance have been documented, no clear mechanism for metronidazole resistance or a role for plasmids in antimicrobial resistance has been described for CD. Here, we report genome sequences of seven susceptible and sixteen resistant CD isolates...

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Identifiers

PMID: 32001686
DOI: 10.1038/s41467-020-14382-1
PMCID: PMC6992631

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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