Article

p63 and PITX1 sustain a pre-invasive malignant keratinocyte population in squamous cell carcinoma precursors

2026-05-24

Abstract excerpt

<h4>Background: </h4> Cutaneous squamous cell carcinoma (cSCC) is among the most common human cancers, yet the cellular identity and molecular programs of its preinvasive precursor, actinic keratosis (AK), remains poorly defined. <h4>Methods:</h4> We applied CITE-seq to patient-matched AK, UV-exposed normal skin, and non-UV-exposed normal skin (n=5 patients, 12 biopsies) and performed spatial whole-transcriptome p...

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Literature Corpus work: 25c0fd7a-d44c-5882-a6ac-d3c7844214a5
DOI: 10.64898/2026.05.21.725073

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