Article
Invasive squamous cell carcinomas and precursor lesions on UV-exposed epithelia demonstrate concordant genomic complexity in driver genes.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Nov 2020
Lazo de la Vega Lorena, Bick Nolan, Hu Kevin, Rahrig Samantha E, Silva Camilla Duarte, Matayoshi Suzana, Picciarelli Patricia, Wang Xiaoming, Sugar Alan, Soong Hunson Kaz, Mian Shahzad I, Robinson Dan R, Chinnaiyan Arul M, Demirci Hakan, Daniels Anthony B, Worden Francis, Eberhart Charles G, Tomlins Scott A, Rao Rajesh C, Harms Paul W
Abstract excerpt
Although squamous cell carcinomas (SCC) are the most frequent human solid tumor at many anatomic sites, the driving molecular alterations underlying their progression from precursor lesions are poorly understood, especially in the context of photodamage. Therefore, we used high-depth, targeted next-generation sequencing (NGS) of RNA and DNA from routine tissue samples to characterize the progression of both well-...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.