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Article

The Genomic Landscape of Actinic Keratosis.

The Journal of investigative dermatology - 1 Jul 2021

Thomson Jason, Bewicke-Copley Findlay, Anene Chinedu Anthony, Gulati Abha, Nagano Ai, Purdie Karin, Inman Gareth J, Proby Charlotte M, Leigh Irene M, Harwood Catherine A, Wang Jun

Abstract excerpt

Actinic keratoses (AKs) are lesions of epidermal keratinocyte dysplasia and are precursors for invasive cutaneous squamous cell carcinoma (cSCC). Identifying the specific genomic alterations driving the progression from normal skin to skin with AK to skin with invasive cSCC is challenging because of the massive UVR-induced mutational burden characteristic at all stages of this progression. In this study, we...

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Source

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Identifiers

PMID: 33482222
DOI: 10.1016/j.jid.2020.12.024
PMCID: PMC8221374

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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