Article

<i>Salmonella</i> actively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner

2022-12-04

Abstract excerpt

<h4>Summary</h4> The transcription factor TFEB drives expression of lysosomal, autophagic, and immune-responsive genes in response to LPS and phagocytosis. Interestingly, compounds that promote TFEB activity enhance bactericidal activity while intracellular pathogens like Mycobacterium and Salmonella repress TFEB. However, Salmonella enterica sv. Typhimurium ( S. Typhimurium) was reported to actively stimulat...

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Literature Corpus work: d3987eb0-703e-5cea-bbf1-d1663ce6790c
DOI: 10.1101/2022.12.03.518968

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