Back to search

Article

A small-scale shRNA screen in primary mouse macrophages identifies a role for the Rab GTPase Rab1b in controlling <i>Salmonella</i> Typhi growth

2020-12-01

Abstract excerpt

Salmonella Typhi, the causative agent of typhoid fever, a life-threatening systemic infection, is a human restricted bacterial pathogen. A fundamental aspect of S . Typhi pathogenesis is its ability to survive in human macrophages but not in macrophages from other animals (i.e. mice). Despite the importance of macrophages in establishing systemic S . Typhi infection, the mechanisms that macrophages use to contro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b60b21df-381a-5129-8c0b-66fdc768f343
DOI
10.1101/2020.12.01.406090
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A small-scale shRNA screen in primary mouse macrophages identifies a role for the Rab GTPase Rab1b in controlling <i>Salmonella</i> Typhi growthDOI 10.1101/2020.12.01.406090
A genome-wide CRISPR screen defines host determinants of early <i>Brucella</i> infection in human macrophage-like cellsSemantic proximity
Lipidation of a bacterial effector is critical for bacterial evasion of host-defenseSemantic proximity
Selection of Salmonella enterica serovar Typhi genes involved during interaction with human macrophages by screening of a transposon mutant library.Semantic proximity
Salmonella enterica Serovar Typhi and the Pathogenesis of Typhoid FeverSemantic proximity
Transcriptional profiling links unique human macrophage phenotypes to the growth of intracellular Salmonella enterica serovar Typhi.Semantic proximity
Multimodal temporal mapping of macrophage transcriptome remodeling during <i>Salmonella</i> infectionSemantic proximity
VSIG4-Expressing Macrophages Contribute To Anti-Parasitic And Anti-Metastatic Responses In The Peritoneal CavitySemantic proximity
Dynamics of growth and dissemination of Salmonella in vivoSemantic proximity
<i>Toxoplasma</i> -proximal and distal control by GBPs in human macrophagesSemantic proximity
Dynamics of macrophage polarization support Salmonella persistence in a whole living organism.Semantic proximity
Distinct CCR2(+) Gr1(+) cells control growth of the Yersinia pestis ΔyopM mutant in liver and spleen during systemic plague.Semantic proximity
Toll‐like receptor 4 signalling through MyD88 is essential to control <i>Salmonella enterica</i> serovar Typhimurium infection, but not for the initiation of bacterial clearanceSemantic proximity
Select a neighboring publication to make it the new centre.