Article

The homeobox transcription factor Cux1 coordinates postnatal epithelial developmental timing but is dispensable for lung organogenesis and regeneration

2024-03-29

Abstract excerpt

Lung epithelial progenitors use a complex network of known and predicted transcriptional regulators to influence early lung development. Here, we evaluate the function of one predicted regulator, Cux1, that we identified from transcriptional regulatory analysis of the SOX9 + distal lung progenitor network. We generated a new Cux1-floxed mouse model and created an epithelial-specific knockout of Cux1 using Shh-Cre...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 256df573-e544-5f86-b9a8-e7cbc3838c83
DOI: 10.1101/2024.03.26.586673

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The homeobox transcription factor Cux1 coordinates postnatal epithelial developmental timing but is dispensable for lung organogenesis and regenerationDOI 10.1101/2024.03.26.586673Read

Decoding the IGF1 Signaling Gene Regulatory Network Behind Alveologenesis from A Mouse Model of Bronchopulmonary DysplasiaSemantic proximity Read

Key Mechanisms of Early Lung DevelopmentSemantic proximity Read

FGF10 Triggers De Novo Alveologenesis in a Bronchopulmonary Dysplasia Model: Impact on Resident Mesenchymal Niche CellsSemantic proximity Read

The Lineage-Specific Transcription Factor CDX2 Navigates Dynamic Chromatin to Control Distinct Stages of Intestine DevelopmentSemantic proximity Read

<i>Foxf1</i> is required for the specification and maintenance of pulmonary capillary identitySemantic proximity Read

Postnatally induced TBX4 insufficiency confers pulmonary hypertension and impairs lung development in infant mice.Semantic proximity Read

LIN28-mediated gene regulatory loops synchronize developmental transitions throughout organogenesisSemantic proximity Read

Transcription factors in mouse lung development and function.Semantic proximity Read

HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestineSemantic proximity Read

Foxp2 and Foxp1 cooperatively regulate lung and esophagus development.Semantic proximity Read

β-Catenin maintains lung epithelial progenitors after lung specificationSemantic proximity Read

Primate-specific ZNF808 is essential for pancreatic development in humansSemantic proximity Read