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Article

Identification of Wee1 as Target in Combination with Avapritinib for the Treatment of Gastrointestinal Stromal Tumor

2020-06-08

Abstract excerpt

Management of gastrointestinal stromal tumor (GIST) has been revolutionized by the identification of activating mutations in KIT and PDGFRA, and the clinical application of receptor tyrosine kinase (RTK) inhibitors in the advanced disease setting. Stratification of GIST into molecularly defined subsets provides insight into clinical behavior and response to approved targeted therapies. Although these RTK inhibitor...

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Literature Corpus work
254fa2e6-ebdf-5c10-b50c-1c97be164332
DOI
10.1101/2020.06.07.138693
Open publication

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Identification of Wee1 as Target in Combination with Avapritinib for the Treatment of Gastrointestinal Stromal TumorDOI 10.1101/2020.06.07.138693
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