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Article

Targeted Therapy for Advanced Gastrointestinal Stromal Tumors: Evolution and Future Directions.

Drug design, development and therapy - 1 Jan 2026

Wang Xiao-Dong, Shou Chun-Hui, Chen Sheng-Chuan, Hong Yan-Yun, Zhu Kan-Kai, Yang Wei-Li, Yu Ji-Ren

Abstract excerpt

Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor of the gastrointestinal tract, with its pathogenesis primarily linked to activating mutations in the KIT or platelet derived growth factor receptor alpha (PDGFRA) genes. Surgical resection remains the standard curative treatment for localized GIST; however, ~50% of patients eventually develop recurrence or metastasis. Since the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41939436
DOI: 10.2147/DDDT.S594043
PMCID: PMC13050227

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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