Article
Identification of Wee1 as a target in combination with avapritinib for gastrointestinal stromal tumor treatment.
JCI insight - 25 Jan 2021
Ye Shuai, Sharipova Dinara, Kozinova Marya, Klug Lilli, D'Souza Jimson, Belinsky Martin G, Johnson Katherine J, Einarson Margret B, Devarajan Karthik, Zhou Yan, Litwin Samuel, Heinrich Michael C, DeMatteo Ronald, von Mehren Margaret, Duncan James S, Rink Lori
Abstract excerpt
Management of gastrointestinal stromal tumors (GISTs) has been revolutionized by the identification of activating mutations in KIT and PDGFRA and clinical application of RTK inhibitors in advanced disease. Stratification of GISTs into molecularly defined subsets provides insight into clinical behavior and response to approved targeted therapies. Although these RTK inhibitors are effective in most GISTs,...
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