Article
Precision medicine in gastrointestinal stromal tumors.
Discovery medicine - 1 Jan 2000
Florou Vaia, Trent Jonathan C, Wilky Breelyn A
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) are rare soft tissue sarcomas of the gastrointestinal tract, with most carrying conserved driver mutations in the tyrosine kinase receptors KIT or PDGFRα. The use of targeted therapy against these mutations in GISTs is one of the most successful examples of precision medicine in solid tumors, beginning in 2002 with the development of imatinib, a small molecule tyrosine...
Topics
Join the communities discussing this publication.